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Cialis Buy Pakistan for the treatment of erectile dysfunction. Cialis Buy Pakistan is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Buy Pakistan leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Online Snabb Leverans has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Buy Pakistan is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Buy Pakistan on PDE5 is more active than on other PDES. Cialis Buy Pakistan is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Buy Pakistan is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Buy Pakistan is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Buy Pakistan is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

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The efficacy and safety of Can I Buy Cialis Over The Counter Uk (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Pakistan 1 time/day. In studies of the primary efficacy of Cialis Buy Pakistan at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis Buy Pakistan at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

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