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Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.


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Information

Clinical pharmacology

Cialis Uae Price is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Uae Price leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Price In Uae Dirham has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Uae Price is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae Price on PDE-5 is more active than on other PDES. Cialis Uae Price is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae Price is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Uae Price is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Uae Price is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Kaufen Online Rezeptfrei improves erection and increases the possibility of a full sexual intercourse.

Cialis Uae Price in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Online Snabb Leverans does not cause a significant change in heart rate.

Cialis Uae Price does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Kaufen Ohne Rezept Erfahrungen on visual acuity, electroretinogram, intraocular pressure and pupil size.

Dosage and administration

Inside. Use of Cialis Uae Price Cialis Uae Price according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Uae Price. The maximum daily dose of Cialis Buy Dubai is 20 mg. the Use of Cialis Uae Price according to the indication of BPH or ED/BPH. The recommended dose of Cialis Uae Price when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Uae Price is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Uae Price at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae Price in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Denmark practically displayed.

Interaction with other drugs

Cialis Uae Price is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Buy Malaysia. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Uae Price reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Online Kaufen Paypal on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Uae Price compared to placebo.

The efficacy and safety of Cialis Uae Price (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Uae Price 1 time per day. In studies of the primary efficacy of Cialis Uae Price at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Ireland To Buy at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Uae Price in patients with BPH — inhibition of PDE-5 Cialis Online Kopen Nederland, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Uae Price Cialis Uae Price according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Denmark. The maximum daily dose of Cialis Uae Price is 20 mg.

The use of Cialis Uae Price Cialis Uae Price for indication of BPH or ED/BPH.The recommended dose of Cialis Uae Price when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Buy Cialis Miami once a day is not recommended.

Effect of other drugs on Cialis Uae Price

Cialis Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Online Kopen Nederland in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae Price in a single dose by 107% and Smachna 15% relative to the AUC values for Comprar Cialis Online En Usa Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Uae Price in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Uae Price activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Online Bestellen Erfahrungsberichte (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Online Kaufen Ohne Rezept Erfahrungen Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Uae Price in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Generico Online Italia Consegna Veloce reduces the rate of absorption of Cialis Uae Price without changing the area under the pharmacokinetic curve for Cialis Uae Price. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Uae Price.

The safety and effectiveness of the combination of Cialis Uae Price with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Uae Price does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

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