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Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Farmacia Online España. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Farmacia Online España reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated


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Information

Effect of Cialis Farmacia Online España on other drugs

It is known that Cialis Online Snabb Leverans increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated.

Cialis Online Italia Consegna Veloce does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Farmacia Online España does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Price In Uae Dirham does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Farmacia Online España does not affect the action of warfarin against PV.

Cialis 20 Mg Price Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Online Kaufen österreich has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis De Vanzare Online should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Farmacia Online España in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Where Can I Buy Cialis Over The Counter Usa with doxazosin is contraindicated. When using Cialis Farmacia Online España healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Farmacia Online España did not affect the concentration of alcohol, nor did alcohol affect the concentration of Buy Lilly Cialis Uk. At high doses of alcohol (0.7 g/kg), Cialis Farmacia Online España did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Buy Liquid Cialis in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Farmacia Online España has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Pharmacokinetics

The pharmacokinetics of Cialis Price In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Farmacia Online España in persons without erectile dysfunction. Absorption After taking Cialis Kuala Lumpur Online inside Cialis Farmacia Online España is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Farmacia Online España does not depend on the meal, so Cialis Farmacia Online España can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis Farmacia Online España in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Cialis Farmacia Online España 1 time/day. The average Vd is about 63 liters, which indicates that Cialis Farmacia Online España is distributed in the tissues of the body. The plasma protein binding of Cialis Farmacia Online España at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis Buy South Africa is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Online Kaufen Ohne Rezept. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Cialis Farmacia Online España when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Farmacia Online España is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Farmacia Online España when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Farmacia Online España (AUC), patients with severe renal insufficiency are not recommended to use Cialis Online Italia Consegna Veloce. The pharmacokinetics of Cialis Online San Marino in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Farmacia Online España to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis Online Miglior Prezzo. In patients with diabetes mellitus during the use of Cialis Farmacia Online España AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Farmacia Online España pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Farmacia Online España is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Farmacia Online España, Cialis Farmacia Online España is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Farmacia Online España.

Side effects and overdose

Due to the well-studied experience of Cialis Farmacia Online España, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Dosage and administration

Inside. Use of Cialis Farmacia Online España Cialis Farmacia Online España according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Farmacia Online España at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Farmacia Online España. The maximum daily dose of Cialis 5 Mg Online Italia is 20 mg. the Use of Cialis Farmacia Online España according to the indication of BPH or ED/BPH. The recommended dose of Cialis Farmacia Online España when used once a day is 5 mg; Cialis Farmacia Online España should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Farmacia Online España is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Farmacia Online España at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Farmacia Online España in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Farmacia Online España practically displayed.

Interaction with other drugs

Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Farmacia Online España. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Farmacia Online España reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated

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