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Buy Cialis Johannesburg for the treatment of erectile dysfunction. Buy Cialis Johannesburg is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Buy Cialis Johannesburg leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Johannesburg has no effect in the absence of sexual arousal.


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The effect on the body Buy Cialis Johannesburg is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Buy Cialis Johannesburg is based on the properties of Buy Cialis Johannesburg, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

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Inside. Use of Buy Cialis Johannesburg Cialis Legal Online Bestellen according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Johannesburg at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Buy Cialis Johannesburg is 20 mg. the Use of Buy Cialis Johannesburg according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Johannesburg when used once a day is 5 mg; Buy Cialis Johannesburg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Johannesburg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Buy Cialis Johannesburg at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Buy Japan in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Liquid Cialis practically displayed.

Interaction with other drugs

Buy Cialis Johannesburg is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Online Kaufen Legal. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Generico Online Mexico reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Johannesburg enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Can You Buy Cialis Over The Counter Canada on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Online Italia Consegna Veloce in patients receiving nitrates is contraindicated

Mechanism of action

The active substance of Buy Cialis Johannesburg is Buy Cialis Johannesburg, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Johannesburg.

Rules of admission

The duration of the generic Buy Cialis Johannesburg reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis Johannesburg should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Recommendations and contraindications

Be sure to consult your doctor before taking Buy Cialis Over The Counter In Canada pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Comprar Cialis Online Canada is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
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Side effects and overdose

Due to the well-studied experience of Buy Cialis Johannesburg, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

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