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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Kuala Lumpur Online on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Farmacia Online España compared to placebo.

The efficacy and safety of Cialis Farmacia Online España (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Farmacia Online España 1 time per day. In studies of the primary efficacy of Cialis Farmacia Online España at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Farmacia Online España at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Farmacia Online España in patients with BPH — inhibition of PDE-5 Cialis Farmacia Online España, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Buy South Africa Cialis Online Kaufen Ohne Rezept according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Farmacia Online España at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Farmacia Online España. The maximum daily dose of Cialis Farmacia Online España is 20 mg.

The use of Cialis Farmacia Online España Cialis Online Italia Consegna Veloce for indication of BPH or ED/BPH.The recommended dose of Cialis Online San Marino when used once a day is 5 mg; Cialis Farmacia Online España should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Online Miglior Prezzo once a day is not recommended.

Pharmacokinetics

The pharmacokinetics of Cialis Farmacia Online España in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Farmacia Online España in persons without erectile dysfunction.

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After taking Cialis Farmacia Online España inside Cialis Farmacia Online España is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Farmacia Online España does not depend on the meal, so Cialis Farmacia Online España® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Farmacia Online España in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Farmacia Online España 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Farmacia Online España is distributed in the tissues of the body.

The plasma protein binding of Cialis Farmacia Online España at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis Farmacia Online España is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis 5 Mg Online Italia. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Farmacia Online España when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Farmacia Online España is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Farmacia Online España when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Farmacia Online España (AUC), patients with severe renal insufficiency are not recommended to use Cialis Farmacia Online España®.

The pharmacokinetics of Cialis Farmacia Online España in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Farmacia Online España Cialis Farmacia Online España® patients with severe liver failure must first assess the risk and benefit of Cialis Farmacia Online España.

In patients with diabetes mellitus during the use of Cialis Farmacia Online España AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Be sure to consult your doctor before taking Cialis Farmacia Online España pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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