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Cialis (tadalafil)

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Quick Overview

Cialis Cost In Uae for the treatment of erectile dysfunction. Cialis Cost In Uae is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Cost In Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Cost In Uae has no effect in the absence of sexual arousal.


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Information

Mechanism of action

The active substance of Cialis Cost In Uae is Buy Cialis Over The Counter Usa, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Johannesburg.

Rules of admission

The duration of the generic Cialis Cost In Uae reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Cost In Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Dosage and administration

Inside. Use of Cialis Cost In Uae Cialis Cost In Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Cost In Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis In Makati. The maximum daily dose of Cialis Cost In Uae is 20 mg. the Use of Cialis Online Kaufen Forum according to the indication of BPH or ED/BPH. The recommended dose of Cialis Cost In Uae when used once a day is 5 mg; Cialis Cost In Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Cost In Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Cost In Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Online Kaufen Ohne Rezept in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Medication practically displayed.

Interaction with other drugs

Cialis Cost In Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Cost In Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Cost In Uae reduced the rate of absorption of the latter without changing the AUC. Cialis Cost In Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Cost In Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Tablets In Uae in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Cialis Cost In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Cost In Uae in persons without erectile dysfunction. Absorption After taking Cialis Cost In Uae inside Viagra Cialis Vendita Online is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Taiwan does not depend on the meal, so Cialis Cost In Uae can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis Cost In Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Cialis Online Kaufen Ohne Rezept 1 time/day. The average Vd is about 63 liters, which indicates that Cialis Cost In Uae is distributed in the tissues of the body. The plasma protein binding of Cialis Malaysia Where To Buy at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis 5mg Price In Uae is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Cost In Uae. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Cialis Cost In Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Cost In Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Cost In Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Cost In Uae (AUC), patients with severe renal insufficiency are not recommended to use Comprar Cialis Online En Usa. The pharmacokinetics of Cialis Cost In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Where Can You Buy Cialis Over The Counter to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Buy Cialis Super Active. In patients with diabetes mellitus during the use of Cialis Cost In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Cost In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Cost In Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Generico Online Recensioni, Cialis Cost In Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Cost In Uae.

Side effects and overdose

Due to the well-studied experience of Cialis Cost In Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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