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Information

Pharmacokinetics

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Suction

After taking Cialis Farmacia Online España inside Cialis 20mg Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Italia Consegna Veloce does not depend on the meal, so Cialis Farmacia Online España® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Price In Uae Dirham in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Farmacia Online España 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis 20 Mg Price Uae is distributed in the tissues of the body.

The plasma protein binding of Cialis Online Kaufen österreich at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis De Vanzare Online is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Farmacia Online España. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Where Can I Buy Cialis Over The Counter Usa when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Farmacia Online España is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Farmacia Online España when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Lilly Cialis Uk (AUC), patients with severe renal insufficiency are not recommended to use Cialis Farmacia Online España®.

The pharmacokinetics of Buy Liquid Cialis in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Farmacia Online España Cialis Price In Uae® patients with severe liver failure must first assess the risk and benefit of Cialis Farmacia Online España.

In patients with diabetes mellitus during the use of Cialis Kuala Lumpur Online AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Dosage and administration

Inside. Use of Cialis Farmacia Online España Cialis Farmacia Online España according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Farmacia Online España at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Farmacia Online España. The maximum daily dose of Cialis Farmacia Online España is 20 mg. the Use of Cialis Farmacia Online España according to the indication of BPH or ED/BPH. The recommended dose of Cialis Farmacia Online España when used once a day is 5 mg; Cialis Buy South Africa should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Online Kaufen Ohne Rezept is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Farmacia Online España at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Farmacia Online España in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Farmacia Online España practically displayed.

Interaction with other drugs

Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Online Italia Consegna Veloce. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Online San Marino reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Online Miglior Prezzo on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated

Pharmacological action

Cialis Farmacia Online España for the treatment of erectile dysfunction. Cialis Farmacia Online España is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Farmacia Online España leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Farmacia Online España has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Farmacia Online España is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Farmacia Online España on PDE5 is more active than on other PDES. Cialis Farmacia Online España is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Farmacia Online España is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Farmacia Online España is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Farmacia Online España is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis 5 Mg Online Italia improves erection and increases the possibility of a full sexual intercourse.

Cialis Farmacia Online España in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Farmacia Online España does not cause a significant change in heart rate. Cialis Farmacia Online España does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis Farmacia Online España on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis Farmacia Online España on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Farmacia Online España compared to placebo.

The efficacy and safety of Cialis Farmacia Online España (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Farmacia Online España 1 time/day. In studies of the primary efficacy of Cialis Farmacia Online España at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis Farmacia Online España at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Farmacia Online España pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Farmacia Online España is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Farmacia Online España, Cialis Farmacia Online España is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Online Bestellen Erfahrungen.

Side effects and overdose

Due to the well-studied experience of Cialis Farmacia Online España, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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